Transcription factor SOX18 is expressed in human coronary atherosclerotic lesions and regulates DNA synthesis and vascular cell growth.

@article{GarcaRamrez2005TranscriptionFS,
  title={Transcription factor SOX18 is expressed in human coronary atherosclerotic lesions and regulates DNA synthesis and vascular cell growth.},
  author={Marta Garc{\'i}a-Ram{\'i}rez and Jos{\'e} L Mart{\'i}nez-Gonz{\'a}lez and Josep Oriol Juan-Babot and Cristina Rodr{\'i}guez and L Badimon},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2005},
  volume={25 11},
  pages={2398-403}
}
OBJECTIVE SOX18, a member of the SOX gene family (SRY-like 3-hydroxy-3-methylglutaryl box gene), is a transcription factor expressed in the development of blood vessels during embryogenesis. We analyzed SOX18 expression in human coronary atherosclerotic lesions and investigated its potential function in vascular cells. METHODS AND RESULTS In advanced human coronary atherosclerotic lesions, SOX18 immunostaining was localized in endothelial cells (on the luminal surface, in vasa vasorum, and in… CONTINUE READING

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