Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes.

@article{Tsujita2014TranscriptionFN,
  title={Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes.},
  author={Tadayuki Tsujita and Vivian Peirce and Liam Baird and Yuka Matsuyama and Misaki Takaku and Shawn V Walsh and Julian Leether Griffin and Akira Uruno and Masayuki Yamamoto and John D. Hayes},
  journal={Molecular and cellular biology},
  year={2014},
  volume={34 20},
  pages={3800-16}
}
Liver-specific Nrf1 (NF-E2-p45-related factor 1) knockout mice develop nonalcoholic steatohepatitis. To identify postnatal mechanisms responsible for this phenotype, we generated an inducible liver-specific Nrf1 knockout mouse line using animals harboring an Nrf1(flox) allele and a rat CYP1A1-Cre transgene (Nrf1(flox/flox)::CYP1A1-Cre mice). Administration of 3-methylcholanthrene (3-MC) to these mice (Nrf1(flox/flox)::CYP1A1-Cre+3MC mice) resulted in loss of hepatic Nrf1 expression. The livers… CONTINUE READING