Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoeitin/MGDF in megakaryocyte development

Abstract

Despite the importance of blood platelets in health and disease, the mechanisms regulating their formation within megakaryocytes are unknown. We generated mice lacking the hematopoietic subunit (p45) of the heterodimeric erythroid transcription factor NF-E2. Unexpectedly, NF-E2-/- mice lack circulating platelets and die of hemorrhage; their megakaryocytes… (More)
DOI: 10.1016/0092-8674(95)90531-6

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@article{Shivdasani1995TranscriptionFN, title={Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoeitin/MGDF in megakaryocyte development}, author={Ramesh A. Shivdasani and Margery F Rosenblatt and Dorothea Zucker-Franklin and Carl W. Jackson and Pamela S. Hunt and Chris J.M Saris and Stuart H Orkin}, journal={Cell}, year={1995}, volume={81}, pages={695-704} }