Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo.


Emerging evidence suggests that myocyte enhancer factor 2 (MEF2) transcription factors act as effectors of neurogenesis in the brain, with MEF2C the predominant isoform in developing cerebrocortex. Here, we show that conditional knockout of Mef2c in nestin-expressing neural stem/progenitor cells (NSCs) impaired neuronal differentiation in vivo, resulting in… (More)
DOI: 10.1073/pnas.0802876105