Transcription factor MEF2A mutations in patients with coronary artery disease.

@article{Bhagavatula2004TranscriptionFM,
  title={Transcription factor MEF2A mutations in patients with coronary artery disease.},
  author={Madhusudan Bhagavatula and Chun Guang Fan and Gong-Qing Shen and June Cassano and Edward F Plow and Eric J. Topol and Qing Wang},
  journal={Human molecular genetics},
  year={2004},
  volume={13 24},
  pages={
          3181-8
        }
}
Coronary artery disease (CAD), including its most serious complication myocardial infraction (MI), is the leading cause of death in the US and developed countries. We recently discovered that a seven-amino acid deletion in MEF2A, a transcription factor with a high level of expression in the endothelium of coronary arteries, co-segregates with CAD/MI in one family, and it suppresses transcription activation activity of MEF2A by a dominant-negative mechanism. In this study, we used single-strand… CONTINUE READING

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