Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells.

@article{Sasaki2015TranscriptionFI,
  title={Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells.},
  author={Haruka Sasaki and Daisuke Kurotaki and Naoki Osato and Hideaki Sato and Izumi Sasaki and Shinji Koizumi and Hongsheng Wang and Chika Kaneda and Akira Nishiyama and Tsuneyasu Kaisho and Hiroyuki Aburatani and Herbert C. Morse and Keiko Ozato and Tomohiko Tamura},
  journal={Blood},
  year={2015},
  volume={125 2},
  pages={
          358-69
        }
}
Basophils and mast cells play critical roles in host defense against pathogens and allergic disorders. However, the molecular mechanism by which these cells are generated is not completely understood. Here we demonstrate that interferon regulatory factor-8 (IRF8), a transcription factor essential for the development of several myeloid lineages, also regulates basophil and mast cell development. Irf8(-/-) mice displayed a severe reduction in basophil counts, which was accounted for by the… 

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Regulation of basophil and mast cell development by transcription factors.

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...

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