Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells.

@article{Sasaki2015TranscriptionFI,
  title={Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells.},
  author={Haruka Sasaki and D. Kurotaki and N. Osato and Hideaki Sato and I. Sasaki and S. Koizumi and Hongshen Wang and C. Kaneda and A. Nishiyama and T. Kaisho and H. Aburatani and H. Morse and K. Ozato and T. Tamura},
  journal={Blood},
  year={2015},
  volume={125 2},
  pages={
          358-69
        }
}
Basophils and mast cells play critical roles in host defense against pathogens and allergic disorders. However, the molecular mechanism by which these cells are generated is not completely understood. Here we demonstrate that interferon regulatory factor-8 (IRF8), a transcription factor essential for the development of several myeloid lineages, also regulates basophil and mast cell development. Irf8(-/-) mice displayed a severe reduction in basophil counts, which was accounted for by the… Expand
Regulation of basophil and mast cell development by transcription factors.
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Transcriptional regulation of mast cell and basophil lineage commitment
Transcriptional and Epigenetic Regulation of Innate Immune Cell Development by the Transcription Factor, Interferon Regulatory Factor-8.
  • D. Kurotaki, T. Tamura
  • Biology, Medicine
  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • 2016
Loss of IRF8 Inhibits the Growth of Diffuse Large B-cell Lymphoma
Interferon regulatory factor 8 governs myeloid cell development.
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