Transcription factor GATA4 is activated but not required for insulin-like growth factor 1 (IGF1)-induced cardiac hypertrophy.

@article{Bisping2012TranscriptionFG,
  title={Transcription factor GATA4 is activated but not required for insulin-like growth factor 1 (IGF1)-induced cardiac hypertrophy.},
  author={Egbert Bisping and Sadakatsu Ikeda and Miriam Sedej and Paulina Wakula and J. Robert Mcmullen and Oleg Tarnavski and Simon Sedej and Seigo Izumo and William T. Pu and Burkert Pieske},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 13},
  pages={
          9827-34
        }
}
Insulin-like growth factor 1 (IGF1) promotes a physiological type of cardiac hypertrophy and has therapeutic effects in heart disease. Here, we report the relationship of IGF1 to GATA4, an essential transcription factor in cardiac hypertrophy and cell survival. In cultured neonatal rat ventricular myocytes, we compared the responses to IGF1 (10 nmol/liter) and phenylephrine (PE, 20 μmol/liter), a known GATA4 activator, in concentrations promoting a similar extent of hypertrophy. IGF1 and PE… CONTINUE READING
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