Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death.

  title={Transcription factor GATA4 inhibits doxorubicin-induced autophagy and cardiomyocyte death.},
  author={Satoru Kobayashi and Paul A. Volden and Derek Timm and Kai Mao and Xianmin Xu and Qiangrong Liang},
  journal={The Journal of biological chemistry},
  volume={285 1},
Doxorubicin (DOX) is a potent anti-tumor drug known to cause heart failure. The transcription factor GATA4 antagonizes DOX-induced cardiotoxicity. However, the protective mechanism remains obscure. Autophagy is the primary cellular pathway for lysosomal degradation of long-lived proteins and organelles, and its activation could be either protective or detrimental depending on specific pathophysiological conditions. Here we investigated the ability of GATA4 to inhibit autophagy as a potential… CONTINUE READING
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