Corpus ID: 41825764

Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the Müllerian inhibiting substance promoter.

@article{Viger1998TranscriptionFG,
  title={Transcription factor GATA-4 is expressed in a sexually dimorphic pattern during mouse gonadal development and is a potent activator of the M{\"u}llerian inhibiting substance promoter.},
  author={Robert S. Viger and Carmen Mertineit and Jacquetta Trasler and Mona Nemer},
  journal={Development},
  year={1998},
  volume={125 14},
  pages={
          2665-75
        }
}
Mammalian gonadal development and sexual differentiation are complex processes that require the coordinated expression of a specific set of genes in a strict spatiotemporal manner. Although some of these genes have been identified, the molecular pathways, including transcription factors, that are critical for the early events of lineage commitment and sexual dimorphism, remain poorly understood. GATA-4, a member of the GATA family of transcription factors, is present in the gonads and may be a… Expand
The Role of GATA in Mammalian Reproduction
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  • Biology, Medicine
  • Experimental biology and medicine
  • 2003
TLDR
GATA transcription factors are emerging as critical players in mammalian reproductive development and function and the current knowledge regarding GATA expression and function at all levels of the reproductive axis is reviewed. Expand
GATA factors differentially activate multiple gonadal promoters through conserved GATA regulatory elements.
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It is reported that GATA-4 differentially activates transcription of several genes expressed in the gonads that encode either steroidogenic enzymes, hormones, and a transcription factor known to be essential for gonadal development and function. Expand
Expression of transcription factor GATA-4 during human testicular development and disease.
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It is found that GATA-4 is expressed from early human fetal testicular development to adulthood and abundantly present in Sertoli and Leydig cell tumors, suggesting a relationship to tumorigenesis or tumor progression in somatic cell-derived testicular neoplasms. Expand
Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development.
TLDR
In situ hybridization analysis is shown that two genes identified by this screen, protease nexin-1 (Pn-1) and vanin- 1 (Vnn1), exhibit male-specific expression prior to overt gonadal differentiation and are detected in the somatic portion of the developing gonad, suggesting a possible direct link to the testis-determining pathway for both genes. Expand
Expression of the GATA-4 and GATA-6 transcription factors in the fetal rat gonad and in the ovary during postnatal development and pregnancy
TLDR
In the adult rat, GATA-4 expression was lower in corpora lutea as compared to follicles; whereas, Gata-6 was strongly expressed in both structures. Expand
A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation
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The data provided provide new insights into the molecular mechanisms that contribute to the tissue-specific expression of the SRY and AMH genes in both normal development and certain syndromes of abnormal sex differentiation. Expand
Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2.
TLDR
It is demonstrated that the transcription factor GATA4 and its co-factor FOG2 are required for gonadal differentiation and their physical interaction is required for normal gonadal development. Expand
Developmental expression and spermatogenic stage specificity of transcription factors GATA-1 and GATA-4 and their cofactors FOG-1 and FOG-2 in the mouse testis.
TLDR
FOG-2, in addition to GATA-4, has a role in early gonadal development and sexual differentiation, and FOG-1 at later fetal stages, while Gata-1 executes its action postnatally. Expand
Expression and regulation of transcription factors GATA-4 and GATA-6 in developing mouse testis.
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It is proposed that transcription factors GATA-4 and Gata-6 play differing roles in the maturation and function of testicular somatic cells. Expand
Comparative Expression Analysis of Genes Associated with Gonadal Development in the Mouse
Mammalian sex determination involves differentiation of a bipotential gonad into either testis or ovary which is governed by a complex interplay of various genes that are spatio-temporally expressed.Expand
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TLDR
In examining normal and germ-line defective mutant mice, it is shown that GATA-1 is expressed only in the Sertoli cell lineage in mouse testis and that the expression of this transcription factor is negatively controlled by the maturing germ cells. Expand
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TLDR
GATA-4 and GATA-6 play distinct roles in follicular development and luteinization, and the established role of other Gata-binding proteins in hematopoetic cell differentiation and apoptosis is proposed. Expand
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TLDR
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TLDR
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TLDR
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TLDR
Experiments are described which show that two previously identified members of the GATA family of transcription factors correspond to chicken cDNAs for two distinct factors and another new member of this family corresponds to a third factor designated cGATA-6, and each of these mRNAs displays a differential expression pattern. Expand
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TLDR
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TLDR
A detailed examination of the pattern of expression of KL in postnatal gonads was undertaken, consistent with a role for KL in oocyte growth and in facilitating proliferation and/or differentiation of type A spermatogonia. Expand
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TLDR
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