Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophages.

@article{Cui2008TranscriptionFF,
  title={Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophages.},
  author={Min Yi Cui and Yunlong Huang and Yong Zhao and Jialin C Zheng},
  journal={Journal of immunology},
  year={2008},
  volume={180 2},
  pages={898-906}
}
Macrophages serve as a major reservoir for HIV-1 because a large number of macrophages in the brain and lung are infected with HIV-1 during late stage disease. Recent evidence suggests that those HIV-1-infected macrophages play a key role in contributing to tissue damage in AIDS pathogenesis. Macrophages undergo apoptosis upon HIV-1 infection; however, the… CONTINUE READING