Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements.

@article{Aranburu2001TranscriptionFA,
  title={Transcription factor AP-4 is a ligand for immunoglobulin-kappa promoter E-box elements.},
  author={Alaitz Aranburu and R. Carlsson and Christine Persson and Tomas Leanderson},
  journal={The Biochemical journal},
  year={2001},
  volume={354 Pt 2},
  pages={431-8}
}
Immunoglobulin (Ig)-kappa promoters from humans and mice share conserved sequences. The octamer element is common to all Ig promoters and pivotal for their function. However, other conserved sequence motifs, that differ between Ig variable gene families, are required for normal promoter function. These conserved motifs do not stimulate transcription in the absence of an octamer. One example is an E-box of the E47/E12 type (5'-CAGCTG-3'), which is found in all promoters of the human and murine… CONTINUE READING

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