Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity.

@article{Hu1990TranscriptionFA,
  title={Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity.},
  author={Yi Fei Hu and Bernhard L{\"u}scher and Arie Admon and Nicolas Mermod and Robert Tjian},
  journal={Genes & development},
  year={1990},
  volume={4 10},
  pages={1741-52}
}
Enhancer binding protein AP-4 is a transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence, CAGCTG. Here, we report the molecular cloning and characterization of human AP-4 cDNAs. The deduced amino acid sequence reveals that AP-4 is a helix-loop-helix (HLH) protein. Like other members of this family, the AP-4 HLH motif and the adjacent basic domain are necessary and sufficient to confer site-specific DNA binding. However, unlike other HLH… CONTINUE READING

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