Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP.

@article{Imagawa1987TranscriptionFA,
  title={Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP.},
  author={Masayoshi Imagawa and Robert Chiu and Michael Karin},
  journal={Cell},
  year={1987},
  volume={51 2},
  pages={251-60}
}
We have purified and characterized the 50 kd activator protein 2 (AP-2), another enhancer-binding protein interacting with the human metallothionein IIA (hMT-IIA) gene control region. Purified AP-2 activates transcription in vitro from a hybrid promoter containing hMT-IIA upstream sequences. AP-2 also recognizes control elements of the human growth hormone, c-myc, and H-2Kb genes, and the SV40 and bovine papilloma virus enhancers. Multiple synthetic copies of the hMT-IIA high-affinity AP-2… CONTINUE READING
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