Transcription factor 7-like 2 gene polymorphisms and gestational diabetes mellitus.

  title={Transcription factor 7-like 2 gene polymorphisms and gestational diabetes mellitus.},
  author={Katharina Christiane Klein and Peter Haslinger and Dagmar Bancher-Todesca and Heinz Leipold and Martin Kn{\"o}fler and Ammon Handisurya and Alexandra Kautzky-Willer and Christof Worda},
  journal={The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians},
  volume={25 9},
OBJECTIVE Transcription factor 7-like 2 (TCF7L2) gene polymorphisms were shown to be associated with insulin resistance. We examined two single nucleotide exchanges in this gene in women with gestational diabetes mellitus (GDM) and in women with normal glucose tolerance. METHODS A total of 1800 unselected women were prospectively screened for GDM by oral glucose tolerance test (OGTT) between 24 and 28 weeks of gestation. Two hundred and fifty Caucasian women of this collective, 125 patients… CONTINUE READING

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