Transcription enhances intrachromosomal homologous recombination in mammalian cells.

@article{Nickoloff1992TranscriptionEI,
  title={Transcription enhances intrachromosomal homologous recombination in mammalian cells.},
  author={Jac A. Nickoloff},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 12},
  pages={5311-8}
}
The influence of transcription on homologous intrachromosomal recombination between direct and inverted repeats has been examined by using Chinese hamster ovary cells. Recombination was monitored between two integrated neomycin (neo) genes, including one silent allele and a second allele regulated by the inducible mouse mammary tumor virus promoter. Transcription of mouse mammary tumor virus neo alleles was regulated with the glucocorticoid hormone dexamethasone. Alleles transcribed at high… CONTINUE READING

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