Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand

@article{Ramiro2003TranscriptionEA,
  title={Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand},
  author={A. Ramiro and P. Stavropoulos and M. Jankovic and M. Nussenzweig},
  journal={Nature Immunology},
  year={2003},
  volume={4},
  pages={452-456}
}
Somatic hypermutation and class switch recombination are DNA modification reactions that alter the genes encoding antibodies in B lymphocytes. Both of these distinct reactions require activation-induced deaminase (AID) and transcription. Here we show that in Escherichia coli, as in eukaryotic cells, the mutation frequency is directly proportional to the transcription of target genes. Transcription enhances mutation of the nontemplate DNA strand, which is exposed as single-stranded DNA during… Expand
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