Transcription elongation past O6-methylguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase

Abstract

O(6)-Methylguanine (O(6)-meG) is a major mutagenic, carcinogenic and cytotoxic DNA adduct produced by various endogenous and exogenous methylating agents. We report the results of transcription past a site-specifically modified O(6)-meG DNA template by bacteriophage T7 RNA polymerase and human RNA polymerase II. These data show that O(6)-meG partially… (More)
DOI: 10.1093/nar/gkn657

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@inproceedings{Dimitri2008TranscriptionEP, title={Transcription elongation past O6-methylguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase}, author={Alexandra Dimitri and John A Burns and Suse Broyde and David A. Scicchitano}, booktitle={Nucleic acids research}, year={2008} }