Transcription-driven genome organization: a model for chromosome structure and the regulation of gene expression tested through simulations

  title={Transcription-driven genome organization: a model for chromosome structure and the regulation of gene expression tested through simulations},
  author={Peter R. Cook and Davide Marenduzzo},
  journal={Nucleic Acids Research},
  pages={9895 - 9906}
Abstract Current models for the folding of the human genome see a hierarchy stretching down from chromosome territories, through A/B compartments and topologically-associating domains (TADs), to contact domains stabilized by cohesin and CTCF. However, molecular mechanisms underlying this folding, and the way folding affects transcriptional activity, remain obscure. Here we review physical principles driving proteins bound to long polymers into clusters surrounded by loops, and present a… 

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