Transcription-dependent and transcription-independent nucleosome disruption induced by dioxin.

  title={Transcription-dependent and transcription-independent nucleosome disruption induced by dioxin.},
  author={Jennifer Elizabeth Morgan and James P. Whitlock},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={89 23},
In mouse hepatoma cells, both the regulatory and the transcribed regions of the cyp1a1 gene assume a nucleosomal configuration when the gene is silent; two nucleosomes occupy specific sites at the transcriptional promoter. Activation of transcription by 2,3,7,8-tetrachlorodibenzo-p-dioxin is accompanied by changes in chromatin structure, which depend upon a functional aromatic hydrocarbon (Ah) receptor. In the transcribed region of the gene, nucleosome disruption occurs as a consequence of RNA… CONTINUE READING

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