Transcription-coupled DNA repair is genomic context-dependent.

  title={Transcription-coupled DNA repair is genomic context-dependent.},
  author={Zhaohui Feng and Wenwei Hu and Elena Komissarova and Annie Y. Pao and M -C Hung and Gerald M. Adair and Moon-shong Tang},
  journal={The Journal of biological chemistry},
  volume={277 15},
DNA damage is preferentially repaired in the transcribed strand of many active genes. Although the concept of DNA repair coupled with transcription has been widely accepted, its mechanisms remain elusive. We recently reported that in Chinese hamster ovary cells while ultraviolet light-induced cyclobutane pyrimidine dimers (CPDs) are preferentially repaired in the transcribed strand of dihydrofolate reductase gene, CPDs are efficiently repaired in both strands of adenine… CONTINUE READING

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