Transcription concepts

  title={Transcription concepts},
  author={Ioana Visan},
  journal={Nature Immunology},
The inflammasome is often a ternary complex composed of a sensor molecule, an adaptor and a caspase. Two papers in Cell, by Egelman et al. and Chen et al., throw light on how the AIM2 and NLRP3 inflammasomes assemble. Activation of either inflammasome results in nucleation of the adaptor ASC by components of the sensors AIM2 and NLRP3. Structural and electromicroscopical analysis demonstrates that the nucleated ASC then polymerizes into a structure with distinct prion-like properties. Assembled… CONTINUE READING