Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis

@article{Hasan2001TranscriptionCP,
  title={Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis},
  author={Sameez Hasan and Paul O. Hassa and Ralph Imhof and Michael O Hottiger},
  journal={Nature},
  year={2001},
  volume={410},
  pages={387-391}
}
The transcriptional coactivator p300 interacts with many transcription factors that participate in a broad spectrum of biological activities, such as cellular differentiation, homeostasis and growth control. Mouse embryos lacking both p300 alleles die around mid-gestation, with pleiotropic defects in morphogenesis, in cell differentiation and, unexpectedly, in cell proliferation because of reduced DNA synthesis. Here we show that p300 may have a role in DNA repair synthesis through its… CONTINUE READING

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