Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis

@article{Hasan2001TranscriptionCP,
  title={Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis},
  author={S. Hasan and P. Hassa and R. Imhof and M. Hottiger},
  journal={Nature},
  year={2001},
  volume={410},
  pages={387-391}
}
The transcriptional coactivator p300 interacts with many transcription factors that participate in a broad spectrum of biological activities, such as cellular differentiation, homeostasis and growth control. Mouse embryos lacking both p300 alleles die around mid-gestation, with pleiotropic defects in morphogenesis, in cell differentiation and, unexpectedly, in cell proliferation because of reduced DNA synthesis. Here we show that p300 may have a role in DNA repair synthesis through its… Expand
CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis
Analysis of proliferating cell nuclear antigen (PCNA) associated with DNA.
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