Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver.

@article{Jia2004TranscriptionCP,
  title={Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver.},
  author={Yuzhi Jia and Chao Qi and Papreddy Kashireddi and Sailesh Surapureddi and Yi-jun Zhu and M. Sambasiva Rao and Derek Le Roith and Pierre Chambon and Frank J. Gonzalez and Janardan K. Reddy},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 23},
  pages={24427-34}
}
Nuclear receptor coactivator PBP (peroxisome proliferator-activated receptor (PPAR)-binding protein) functions as a coactivator for PPARs and other nuclear receptors. PBP serves as an anchor for TRAP (thyroid hormone receptor-associated proteins)/mediator multisubunit cofactor transcription complex. Disruption of the PBP/TRAP220 gene results in embryonic lethality around embryonic day 11.5 by affecting placental, cardiac, hepatic, and bone marrow development. Because PPAR isoforms alpha, gamma… CONTINUE READING
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