Transcription by RNA polymerase III: more complex than we thought

  title={Transcription by RNA polymerase III: more complex than we thought},
  author={R. White},
  journal={Nature Reviews Genetics},
  • R. White
  • Published 2011
  • Medicine, Biology
  • Nature Reviews Genetics
  • RNA polymerase (Pol) III is highly specialized for the production of short non-coding RNAs. Once considered to be under relatively simple controls, recent studies using chromatin immunoprecipitation followed by sequencing (ChIP–seq) have revealed unexpected levels of complexity for Pol III regulation, including substantial cell-type selectivity and intriguing overlap with Pol II transcription. Here I describe these novel insights and consider their implications and the questions that remain. 
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