Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks

@inproceedings{Belotserkovskii2013TranscriptionBB,
  title={Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks},
  author={Boris P. Belotserkovskii and Alexander J. Neil and Syed Shayon Saleh and Jane Hae Soo Shin and Sergei M Mirkin and Philip C. Hanawalt},
  booktitle={Nucleic acids research},
  year={2013}
}
The ability of DNA to adopt non-canonical structures can affect transcription and has broad implications for genome functioning. We have recently reported that guanine-rich (G-rich) homopurine-homopyrimidine sequences cause significant blockage of transcription in vitro in a strictly orientation-dependent manner: when the G-rich strand serves as the non-template strand [Belotserkovskii et al. (2010) Mechanisms and implications of transcription blockage by guanine-rich DNA sequences., Proc. Natl… CONTINUE READING

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