Transcription-associated mutational asymmetry in mammalian evolution

  title={Transcription-associated mutational asymmetry in mammalian evolution},
  author={Phil Green and Brent Ewing and Webb Miller and Pamela J. Thomas and NISC Comparative Sequencing Program and Eric D. Green},
  journal={Nature Genetics},
Although mutation is commonly thought of as a random process, evolutionary studies show that different types of nucleotide substitution occur with widely varying rates that presumably reflect biases intrinsic to mutation and repair mechanisms. A strand asymmetry, the occurrence of particular substitution types at higher rates than their complementary types, that is associated with DNA replication has been found in bacteria and mitochondria. A strand asymmetry that is associated with… CONTINUE READING
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