Transcription and replication initiate at separate sites on the vesicular stomatitis virus genome.

@article{Whelan2002TranscriptionAR,
  title={Transcription and replication initiate at separate sites on the vesicular stomatitis virus genome.},
  author={Sean P J Whelan and Gail Williams Wertz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 14},
  pages={
          9178-83
        }
}
The RNA-dependent RNA polymerase of the nonsegmented negative-strand RNA viruses carries out two distinct RNA synthetic processes: transcription of monocistronic, capped, and polyadenylated subgenomic messenger RNAs, and replication by means of the synthesis of a full-length positive-sense copy of the genome. The template for both processes is the negative-sense genomic RNA tightly encapsidated by the viral nucleocapsid protein. By applying UV transcriptional mapping to engineered variants of… CONTINUE READING

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