Transcription activation by FNR: evidence for a functional activating region 2.

@article{Blake2002TranscriptionAB,
  title={Transcription activation by FNR: evidence for a functional activating region 2.},
  author={Timo Blake and Anne M L Barnard and Stephen J W Busby and Jeffrey Green},
  journal={Journal of bacteriology},
  year={2002},
  volume={184 21},
  pages={5855-61}
}
The FNR protein of Escherichia coli controls the transcription of target genes in response to anoxia via the assembly-disassembly of oxygen-labile iron-sulfur clusters. Previous work identified patches of surface-exposed amino acids (designated activating regions 1 and 3 [AR1 and AR3, respectively]) of FNR which allow it to communicate with RNA polymerase (RNAP) and thereby activate transcription. Previously it was thought that FNR lacks a functional activating region 2 (AR2), although… CONTINUE READING