Transcription activation at Escherichia coli FNR-dependent promoters by the gonococcal FNR protein: effects of a novel S18F substitution and comparisons with the corresponding substitution in E. coli FNR.

@article{Overton2003TranscriptionAA,
  title={Transcription activation at Escherichia coli FNR-dependent promoters by the gonococcal FNR protein: effects of a novel S18F substitution and comparisons with the corresponding substitution in E. coli FNR.},
  author={Tim W. Overton and Eleanor G F Reid and Robin Foxall and Harry Smith and Stephen J W Busby and Jeff A. Cole},
  journal={Journal of bacteriology},
  year={2003},
  volume={185 16},
  pages={
          4734-47
        }
}
The Neisseria gonorrhoeae genome encodes a homologue of the Escherichia coli FNR protein (the fumarate and nitrate reductase regulator). Despite its similarity to E. coli FNR, the gonococcal FNR only partially complemented an E. coli fnr mutation. After error-prone PCR mutagenesis of the gonococcal fnr gene, we identified four mutant fnr derivatives carrying the same S18F substitution, and we showed that the mutant FNR could activate transcription from a range of class I and class II FNR… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 36 REFERENCES

Secrets of bacterial transcription initiation taught by the Escherichia coli

  • D. F. Browning, D. Lee, J. Green, S. J. Busby
  • FNR protein,
  • 2002
2 Excerpts

Similar Papers

Loading similar papers…