Transcription Network Analysis by A Sparse Binary Factor Analysis Algorithm

Abstract

Transcription factor activities (TFAs), rather than expression levels, control gene expres- sion and provide valuable information for investigating TF-gene regulations. The underly- ing bimodal or switch-like patterns of TFAs may play important roles in gene regulation. Network Component Analysis (NCA) is a popular method to deduce TFAs and TF-gene control… (More)
DOI: 10.1515/jib-2012-198

Topics

6 Figures and Tables