Transcription Factors with Conserved Binding Sites Near ATOH1 on the POU4F3 Gene Enhance the Induction of Cochlear Hair Cells

@article{Ikeda2014TranscriptionFW,
  title={Transcription Factors with Conserved Binding Sites Near ATOH1 on the POU4F3 Gene Enhance the Induction of Cochlear Hair Cells},
  author={Ryoukichi Ikeda and Kwang K. Pak and Eduardo Chavez and Allen F Ryan},
  journal={Molecular Neurobiology},
  year={2014},
  volume={51},
  pages={672-684}
}
Overexpression of the transcription factor (TF) ATOH1 is known to induce the transformation of nonsensory cells in the organ of Corti into hair cells (HCs). Evaluating DNA 5′ to the coding sequence of the pou4f3 gene, a target of ATOH1 in HCs, we identified in three regions containing clustered binding sites for ATOH1 and several other TFs that are… CONTINUE READING