Transcription Factor NF-κB Is Transported to the Nucleus via Cytoplasmic Dynein/Dynactin Motor Complex in Hippocampal Neurons

@article{Mikenberg2007TranscriptionFN,
  title={Transcription Factor NF-κB Is Transported to the Nucleus via Cytoplasmic Dynein/Dynactin Motor Complex in Hippocampal Neurons},
  author={Ilja Mikenberg and Darius Widera and Aljoscha Kaus and Barbara Kaltschmidt and Christian Kaltschmidt},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={280 - 288}
}
BACKGROUND Long-term changes in synaptic plasticity require gene transcription, indicating that signals generated at the synapse must be transported to the nucleus. Synaptic activation of hippocampal neurons is known to trigger retrograde transport of transcription factor NF-kappaB. Transcription factors of the NF-kappaB family are widely expressed in the nervous system and regulate expression of several genes involved in neuroplasticity, cell survival, learning and memory. PRINCIPAL FINDINGS… CONTINUE READING