Transcription Factor Map Alignment of Promoter Regions

  title={Transcription Factor Map Alignment of Promoter Regions},
  author={Enrique Blanco and Xavier Messeguer and Temple F. Smith and Roderic Guig{\'o}},
  journal={PLoS Computational Biology},
  pages={1377 - 1419}
We address the problem of comparing and characterizing the promoter regions of genes with similar expression patterns. This remains a challenging problem in sequence analysis, because often the promoter regions of co-expressed genes do not show discernible sequence conservation. In our approach, thus, we have not directly compared the nucleotide sequence of promoters. Instead, we have obtained predictions of transcription factor binding sites, annotated the predicted sites with the labels of… CONTINUE READING


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