Transcription Factor IRF8 Governs Enhancer Landscape Dynamics in Mononuclear Phagocyte Progenitors.

@article{Kurotaki2018TranscriptionFI,
  title={Transcription Factor IRF8 Governs Enhancer Landscape Dynamics in Mononuclear Phagocyte Progenitors.},
  author={D. Kurotaki and J. Nakabayashi and A. Nishiyama and Haruka Sasaki and Wataru Kawase and Naofumi Kaneko and Kyoko Ochiai and K. Igarashi and K. Ozato and Yutaka Suzuki and T. Tamura},
  journal={Cell reports},
  year={2018},
  volume={22 10},
  pages={
          2628-2641
        }
}
Monocytes and dendritic cells (DCs), mononuclear phagocytes essential for immune responses, develop from hematopoietic stem cells via monocyte-DC progenitors (MDPs). The molecular basis of their development remains unclear. Because promoter-distal enhancers are key to cell fate decisions, we analyzed enhancer landscapes during mononuclear phagocyte development in vivo. Monocyte- and DC-specific enhancers were gradually established at progenitor stages before the expression of associated genes… Expand
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