Transcription 1 NF-κ B and Enhancer-Binding CREB Scaffolded by CBP / p 300 Regulate CD 59 Expression to Protect Cells from Complement Attack *

@inproceedings{Du2013Transcription1N,
  title={Transcription 1 NF-κ B and Enhancer-Binding CREB Scaffolded by CBP / p 300 Regulate CD 59 Expression to Protect Cells from Complement Attack *},
  author={Yiqun Du and Xiaoyan Teng and Na Wang and Xin Zhang and Jian Chen and Peipei Ding and Qian Qiao and Qingkai Wang and Long Zhang and Chaoqun Yang and Zhangmin Yang and Yiwei Chu and Xiang Du and Xuhui Zhou and Weiguo Hu},
  year={2013}
}
The complement system can be activated spontaneously for immune surveillance or induced to clear invading pathogens, in which the membrane attack complex (MAC, C5b-9) plays a critical role. CD59 is the sole membrane complement regulatory protein (mCRP) that restricts MAC assembly. CD59 therefore protects innocent host cells from attacks by the complement system, and host cells require the constitutive and inducible expression of CD59 to protect themselves from deleterious destruction by… CONTINUE READING