Transcription — guarding the genome by sensing DNA damage

  title={Transcription — guarding the genome by sensing DNA damage},
  author={Mats Ljungman and D. P. Lane},
  journal={Nature Reviews Cancer},
Cells induce the expression of DNA-repair enzymes, activate cell-cycle checkpoints and, under some circumstances, undergo apoptosis in response to DNA-damaging agents. The mechanisms by which these cellular responses are triggered are not well understood, but there is recent evidence that the transcription machinery might be used in DNA-damage surveillance and in triggering DNA-damage responses to suppress mutagenesis. Transcription might also act as a DNA-damage dosimeter where the severity of… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
99 Citations
175 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 99 extracted citations


Publications referenced by this paper.
Showing 1-10 of 175 references

Cancer susceptibility and the functions of BRCA 1 and BRCA 2

  • A. R. Venkitaraman
  • Mol . Cell
  • 2004

Identification of the von Hippel – Lindau tumorsuppressor protein as part of an active E 3 ubiquitin ligase complex

  • K. Iwai
  • Natl Acad . Sci . USA
  • 2004

Similar Papers

Loading similar papers…