Transcription — guarding the genome by sensing DNA damage

@article{Ljungman2004TranscriptionG,
  title={Transcription — guarding the genome by sensing DNA damage},
  author={Mats Ljungman and D. P. Lane},
  journal={Nature Reviews Cancer},
  year={2004},
  volume={4},
  pages={727-737}
}
Cells induce the expression of DNA-repair enzymes, activate cell-cycle checkpoints and, under some circumstances, undergo apoptosis in response to DNA-damaging agents. The mechanisms by which these cellular responses are triggered are not well understood, but there is recent evidence that the transcription machinery might be used in DNA-damage surveillance and in triggering DNA-damage responses to suppress mutagenesis. Transcription might also act as a DNA-damage dosimeter where the severity of… CONTINUE READING

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