Transcription, DNA damage and beyond: the roles of histone ubiquitination and deubiquitination.

  • Hai-Ning Du
  • Published 2012 in Current protein & peptide science

Abstract

Myriad covalent post-translational modifications of histones have been demonstrated to play crucial roles in regulating gene transcription, gene repression, DNA damage and repair, and beyond. It has been long known that these modifications are often dynamic, such as histone ubiquitination and deubiquitination, and the processes through adding and/or… (More)

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