Transcript-specific developmental regulation of polyadenylation in Trypanosoma brucei mitochondria.

  title={Transcript-specific developmental regulation of polyadenylation in Trypanosoma brucei mitochondria.},
  author={Ganapati J Bhat and Andre L. Souza and Jean E. Feagin and Kenneth Stuart},
  journal={Molecular and biochemical parasitology},
  volume={52 2},
Transcripts from many mitochondrial genes in kinetoplastids are heterogeneous in size, often occurring as 2 distinct size classes, but this cannot be accounted for by RNA editing alone. Analyses of transcripts from 6 mitochondrial genes of Trypanosoma brucei indicates that the size variation is due to poly(A) tail length. A larger fraction of CYb, COI and COII transcripts have longer poly(A) tails in procyclic than in bloodstream forms. These transcripts are also more abundant in the procyclic… CONTINUE READING

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