Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1.

@article{Murad2001TranscriptPI,
  title={Transcript profiling in Candida albicans reveals new cellular functions for the transcriptional repressors CaTup1, CaMig1 and CaNrg1.},
  author={Ayman Mansour Murad and Christophe d'Enfert and C. Gaillardin and H{\'e}l{\`e}ne Tournu and Fredj Tekaia and Driss Talibi and Daniel Mar{\'e}chal and V{\'e}ronique Marchais and J. Y. Cottin and Alistair J P Brown},
  journal={Molecular microbiology},
  year={2001},
  volume={42 4},
  pages={981-93}
}
The pathogenic fungus, Candida albicans contains homologues of the transcriptional repressors ScTup1, ScMig1 and ScNrg1 found in budding yeast. In Saccharomyces cerevisiae, ScMig1 targets the ScTup1/ScSsn6 complex to the promoters of glucose repressed genes to repress their transcription. ScNrg1 is thought to act in a similar manner at other promoters. We have examined the roles of their homologues in C. albicans by transcript profiling with an array containing 2002 genes, representing about… CONTINUE READING

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