Transcript length bias in RNA-seq data confounds systems biology

@article{Oshlack2009TranscriptLB,
  title={Transcript length bias in RNA-seq data confounds systems biology},
  author={Alicia Oshlack and Matthew J. Wakefield},
  journal={Biology Direct},
  year={2009},
  volume={4},
  pages={14 - 14}
}
Several recent studies have demonstrated the effectiveness of deep sequencing for transcriptome analysis (RNA-seq) in mammals. As RNA-seq becomes more affordable, whole genome transcriptional profiling is likely to become the platform of choice for species with good genomic sequences. As yet, a rigorous analysis methodology has not been developed and we are still in the stages of exploring the features of the data. We investigated the effect of transcript length bias in RNA-seq data using three… CONTINUE READING
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