Transcript-Specific Expression Profiles Derived from Sequence-Based Analysis of Standard Microarrays

  title={Transcript-Specific Expression Profiles Derived from Sequence-Based Analysis of Standard Microarrays},
  author={Anton G. Moll and Maja Tamara Lindenmeyer and Matthias Kretzler and Peter Jon Nelson and Ralf Zimmer and Clemens David Cohen},
  journal={PLoS ONE},
  pages={185 - 916; author reply 916–917}
BACKGROUND Alternative mRNA processing mechanisms lead to multiple transcripts (i.e. splice isoforms) of a given gene which may have distinct biological functions. Microarrays like Affymetrix GeneChips measure mRNA expression of genes using sets of nucleotide probes. Until recently probe sets were not designed for transcript specificity. Nevertheless, the re-analysis of established microarray data using newly defined transcript-specific probe sets may provide information about expression levels… CONTINUE READING


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