Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells

@article{Arner2015TranscribedEL,
  title={Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells},
  author={Erik Arner and Carsten O. Daub and Kristoffer Vitting-Seerup and Robin Andersson and Berit Lilje and Finn Drabl\os and Andreas Lennartsson and Michelle R{\"o}nnerblad and Olga Hrydziuszko and Morana Vitezic and Tom C. Freeman and Ahmad M. N. Alhendi and Peter Arner and Richard A. Axton and J. Kenneth Baillie and Anthony G. Beckhouse and Beatrice Bodega and James Alexander Briggs and Frank Brombacher and Margaret Davis and Michael Detmar and Anna Ehrlund and Mitsuhiro Endoh and Afsaneh Eslami and Michela Fagiolini and Lynsey Fairbairn and Geoffrey J. Faulkner and Carmelo Ferrai and Malcolm E. Fisher and Lesley M Forrester and Daniel Goldowitz and Reto Guler and Thomas Ha and Mitsuko Hara and Meenhard Herlyn and Tomokatsu Ikawa and Chieko Kai and Hiroshi Kawamoto and Levon M. Khachigian and S. Peter Klinken and Soichi Kojima and Haruhiko Koseki and Sarah Klein and Niklas Mejhert and Ken Miyaguchi and Yosuke Mizuno and Mitsuru Morimoto and Kelly J. Morris and Christine L Mummery and Yutaka Nakachi and Soichi Ogishima and Mariko Okada-Hatakeyama and Yasushi Okazaki and Valerio Orlando and Dmitry Ovchinnikov and Robert Passier and Margaret Patrikakis and Ana Pombo and Xian-Yang Qin and Sugata Roy and Hiroki Sato and Suzana Savvi and Alka Saxena and Anita Schwegmann and Daisuke Sugiyama and Rolf Swoboda and Hiroshi Tanaka and Andru Tomoiu and Louise N. Winteringham and Ernst J Wolvetang and Chiyo Yanagi-Mizuochi and Misako Yoneda and Susan E. Zabierowski and Peter G. Zhang and Imad Abugessaisa and Nicolas Bertin and Alexander D. Diehl and Shiro Fukuda and Masaaki Furuno and Jayson Harshbarger and Akira Hasegawa and Fumi Hori and Sachi Ishikawa-Kato and Yuri Ishizu and Masayoshi Itoh and Tsugumi Kawashima and Miki Kojima and Naoto Kondo and Marina Lizio and Terrence F. Meehan and Christopher J Mungall and Mitsuyoshi Murata and Hiromi Nishiyori-Sueki and Serkan Sahin and Sayaka Nagao-Sato and Jessica Severin and Michiel J. L. de Hoon and Jun Kawai and Takeya Kasukawa and Timo Lassmann and Harukazu Suzuki and Hideya Kawaji and Kim M. Summers and Christine A. Wells and David A. Hume and Alistair R. R. Forrest and Albin Sandelin and Piero Carninci and Yoshihide Hayashizaki},
  journal={Science},
  year={2015},
  volume={347},
  pages={1010-1014}
}
Although it is generally accepted that cellular differentiation requires changes to transcriptional networks, dynamic regulation of promoters and enhancers at specific sets of genes has not been previously studied en masse. Exploiting the fact that active promoters and enhancers are transcribed, we simultaneously measured their activity in 19 human and 14 mouse time courses covering a wide range of cell types and biological stimuli. Enhancer RNAs, then messenger RNAs encoding transcription… CONTINUE READING
120 Citations
27 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 120 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Analysis of the DNA methylome and transcriptome in granulopoiesis reveals timed changes and dynamic enhancer methylation

  • R. Andersson M. Rönnerblad, T. Olofsson, +15 authors A. Lennartsson
  • 2014

Long non - coding RNAs and enhancer RNAs regulate the lipopolysaccharide - induced inflammatory response in human monocytes

  • J. A. Heward, B. Roux, +8 authors D. Sims
  • Nat . Commun .
  • 2014

Similar Papers

Loading similar papers…