Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease

@article{Schweitzer2006TranscranialUI,
  title={Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease},
  author={Katherine Johanna Schweitzer and Theresa Bruessel and Petra Leitner and Rejko Krueger and Peter Bauer and Dirk Woitalla and Juergen Tomiuk and Thomas Gasser and D. Berg},
  journal={Journal of Neurology},
  year={2006},
  volume={254},
  pages={613-616}
}
Hyperechogenicity of the substantia nigra (SN) has been found to be a typical sign in idiopathic Parkinson's disease (PD), prevalent in more than 90% of affected individuals. To see whether SN hyperechogenicity is also characteristic for monogenetically caused PD, we investigated PD patients with alpha-synuclein, LRRK2, parkin, PINK1 and DJ-1 mutations by transcranial sonography (TCS). In all these patients the area of SN echogenicity was significantly larger than in healthy controls, but… CONTINUE READING