Transcranial ultrasound-improved thrombolysis: diagnostic vs. therapeutic ultrasound.

@article{Behrens2001TranscranialUT,
  title={Transcranial ultrasound-improved thrombolysis: diagnostic vs. therapeutic ultrasound.},
  author={Stephan Behrens and Konstantinos Spengos and Michael Daffertshofer and Helmut Schroeck and Carl Erik Dempfle and Michael Hennerici},
  journal={Ultrasound in medicine & biology},
  year={2001},
  volume={27 12},
  pages={
          1683-9
        }
}
Success of stroke treatment with rt-PA depends on rapid vessel recanalization. Enzymatic thrombolysis may be enhanced by additional transcranial application of ultrasound (US). We investigated this novel technique using a 185-kHz probe and compared it to standard diagnostic US. In vitro studies were performed in a continuous pressure tubing system. Clots were placed in a postmortem skull and treated with rt-PA together with or without transtemporal 185-kHz US insonation (2W/cm(2)) and in… CONTINUE READING
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