Transcranial magnetic stimulation accelerates the antidepressant effect of amitriptyline in severe depression: a double-blind placebo-controlled study.

@article{Rumi2005TranscranialMS,
  title={Transcranial magnetic stimulation accelerates the antidepressant effect of amitriptyline in severe depression: a double-blind placebo-controlled study.},
  author={Dem{\'e}trio Ortega Rumi and Wagner F. Gattaz and Sergio P. Rigonatti and Moacyr Alexandro Rosa and Felipe Fregni and Marina Odebrecht Rosa and Carlos Gustavo Mansur and Martin Luiz Myczkowski and Ricardo Alberto Moreno and Marco Antonio Marcolin},
  journal={Biological psychiatry},
  year={2005},
  volume={57 2},
  pages={162-6}
}
BACKGROUND Transcranial magnetic stimulation (TMS) is a noninvasive method to stimulate the cortex, and the treatment of depression is one of its potential therapeutic applications. Three recent meta analyses strongly suggest its benefits in the treatment of depression. The present study investigates whether repetitive TMS (rTMS) accelerates the onset of action and increases the therapeutic effects of amitriptyline. METHODS Forty-six outpatients meeting DSM-IV criteria for nonpsychotic… CONTINUE READING

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