Transcranial brain sonography findings predict disease progression in multiple sclerosis

@article{Walter2009TranscranialBS,
  title={Transcranial brain sonography findings predict disease progression in multiple sclerosis},
  author={Uwe Walter and Sabine Wagner and Sebastian Horowski and Reiner Benecke and Uwe Klaus Zettl},
  journal={Neurology},
  year={2009},
  volume={73},
  pages={1010 - 1017}
}
Objective: In multiple sclerosis (MS), an early neurodegenerative affection of subcortical gray matter has been suggested. Transcranial sonography (TCS) shows hyperechogenic lesions of substantia nigra (SN) and basal ganglia, thought to reflect iron accumulation, in a number of primary neurodegenerative diseases. The present study deals with the question of whether TCS can also display deep gray matter lesions in patients with MS and whether sonographic findings relate to severity and… 

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Substantia nigra hyperechogenicity is a risk marker of Parkinson’s disease: no

  • U. Walter
  • Biology
    Journal of Neural Transmission
  • 2010
TLDR
The present view summarizes current scientific evidence favouring the idea that the TCS finding of SN hyperechogenicity alone may not be a (strong) risk marker of PD.

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...

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