Transcranial Cortical Stimulation in the Treatment of Obsessive-Compulsive Disorders: Efficacy Studies

  title={Transcranial Cortical Stimulation in the Treatment of Obsessive-Compulsive Disorders: Efficacy Studies},
  author={Ghassen Saba and Albert Moukheiber and Antoine Pelissolo},
  journal={Current Psychiatry Reports},
Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are non-invasive brain stimulation methods that became widely used as therapeutic tools during the past two decades especially in cases of depression and schizophrenia. Low frequency rTMS and cathodal effect of tDCS inhibits cortical functioning while high frequency and anodal effect of tDCS have the opposite effect. Prolonged and repetitive application of either methods leads to changes in… 
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Improved understanding of the therapeutic effects of rTMS in OCD will support fine-tuning of the method and help determine how to best optimize the approach via rT MS or dTMS to achieve clinically relevant results.
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Cathode tDCS could be potentially used to regulate obsession-induced anxiety in refractory OCD patients and a statistically significant decrease in the severity of the obsession- induced anxiety was found as a result of cathode tDCs in comparison with the anode and sham stimulation.
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Through the analysis of controlled studies, meta-analyses, and International treatment guidelines, the present article is aimed at providing the state of the art on the use of brain stimulation techniques for the treatment of OCD.
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Repetitive Transcranial Magnetic Stimulation to Supplementary Motor Area in Refractory Obsessive-Compulsive Disorder Treatment: a Sham-Controlled Trial
Low-frequency repetitive transcranial magnetic stimulation applied to the presupplementary area seems ineffective for the treatment of obsessive-compulsive disorder patients, at least in severe and drug-refractory cases such as those included in this study.
Brain Stimulation in Obsessive-Compulsive Disorder (OCD): A Systematic Review
Different brain stimulation techniques are promising as an add-on treatment of refractory OCD, although studies frequently reported inconsistent results.
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Transcranial magnetic stimulation for the treatment of obsessive-compulsive disorder.
There are currently insufficient data from randomised controlled trials to draw any conclusions about the efficacy of transcranial magnetic stimulation in the treatment of obsessive-compulsive disorder.
Safety and efficacy of repetitive transcranial magnetic stimulation in the treatment of obsessive-compulsive disorder: A review
  • N. Jaafari, F. Rachid, A. Pelissolo
  • Psychology
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2012
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Neuropsychiatric applications of transcranial magnetic stimulation: a meta analysis.
Transcranial magnetic stimulation (TMS) is a technology that allows for non-invasive modulation of the excitability and function of discrete brain cortical areas. TMS uses alternating magnetic fields
Treatment of major depression with transcranial direct current stimulation.
The effects of 5 days of anodal stimulation of the left dorsolateral prefrontal cortex in 10 patients with major depression are investigated, finding a significant decrease in the Hamilton Depression Rating Scale and Beck Depression Inventory scores when compared with baseline that was not observed in patients that received sham stimulation.
Augmentation effect of repetitive transcranial magnetic stimulation over the supplementary motor cortex in treatment refractory patients with obsessive compulsive disorder
Low-frequency repetitive transcranial magnetic stimulation over the SMA appears a promising treatment strategy as an add-on treatment in treatment-refractory patients of OCD.
Examining transcranial direct-current stimulation (tDCS) as a treatment for hallucinations in schizophrenia.
The results show promise for treating refractory auditory verbal hallucinations and other selected manifestations of schizophrenia.
Repetitive transcranial magnetic stimulation for the treatment of obsessive compulsive disorder: a double-blind controlled investigation
Two weeks of rTMS over the left DLPFC is ineffective for treatment-resistant OCD and over 20 sessions, there was a significant reduction in total YBOCS scores, but not after controlling for depression.
Right prefrontal repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: a double-blind, placebo-controlled study.
Low-frequency rTMS of the right prefrontal cortex failed to produce significant improvement of OCD and was not significantly different from sham treatment.