Transcobalamin polymorphism 67A->G, but not 776C->G, affects serum holotranscobalamin in a cohort of healthy middle-aged men and women.

@article{Riedel2011TranscobalaminP6,
  title={Transcobalamin polymorphism 67A->G, but not 776C->G, affects serum holotranscobalamin in a cohort of healthy middle-aged men and women.},
  author={Bettina M. Riedel and Anne M. Molloy and Klaus Meyer and Ase Fredriksen and Arve Ulvik and J\orn Schneede and Ebba Nex\o and Geir Hoff and Per Magne Ueland},
  journal={The Journal of nutrition},
  year={2011},
  volume={141 10},
  pages={1784-90}
}
Two polymorphic variants in the gene coding for transcobalamin II (TCN2), TCN2 776C- > G and TCN2 67A- > G, may alter serum holotranscobalamin (holoTC), which in turn may affect cellular uptake of cobalamin (Cbl) and thereby Cbl status indicators. We studied the effects of TCN2 776C- > G and TCN2 67A- > G on blood concentrations of holoTC, Cbl, methylmalonic acid (MMA), and total homocysteine (tHcy) in 2411 individuals (50-64 y) that had been selected on the basis of these TCN2 genotypes from… CONTINUE READING

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