Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans.

@article{GuantRodrguez2003TranscobalaminAM,
  title={Transcobalamin and methionine synthase reductase mutated polymorphisms aggravate the risk of neural tube defects in humans.},
  author={Rosa-Maria Gu{\'e}ant-Rodr{\'i}guez and Claudia Rendeli and Bernard Namour and L. Venuti and Antonio Romano and Guido Anello and P. I. Bosco and Ren{\'e}e Debard and Philippe G{\'e}rard and Massimo Viola and Elio Salvaggio and Jean Louis Gu{\'e}ant},
  journal={Neuroscience letters},
  year={2003},
  volume={344 3},
  pages={189-92}
}
The pathogenic mechanism of neural tube defects may involve genetic polymorphisms and nutritional factors related to homocysteine metabolism. We evaluated the association of polymorphisms of three genes affecting vitamin B12-dependent remethylation of homocysteine, transcobalamin (TC), methionine synthase (MTR) and MTR reductase (MTRR), combined or not with methylenetetrahydrofolate reductase (MTHFR), with the risk of having neural tube defect in 40 children with spina bifida and 58 matched… CONTINUE READING

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